Exosomes and their roles in immune regulation and cancer

DW Greening; SK Gopal; R Xu; RJ Simpson; W Chen

Journal article

Exosomes and their roles in immune regulation and cancer

DW Greening, SK Gopal, R Xu, RJ Simpson, W Chen

Seminars in Cell and Developmental Biology | Published : 2015

DOI: 10.1016/j.semcdb.2015.02.009

Abstract

Exosomes, a subset of extracellular vesicles (EVs), function as a mode of intercellular communication and molecular transfer. Exosomes facilitate the direct extracellular transfer of proteins, lipids, and miRNA/mRNA/DNAs between cells in vitro and in vivo. The immunological activities of exosomes affect immunoregulation mechanisms including modulating antigen presentation, immune activation, immune suppression, immune surveillance, and intercellular communication. Besides immune cells, cancer cells secrete immunologically active exosomes that influence both physiological and pathological processes. The observation that exosomes isolated from immune cells such as dendritic cells (DCs) modulat..

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University of Melbourne Researchers

David Greening Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The authors are supported, in part, by the NHMRC program grant 567122 (W.C.), NHMRC program grant 487922 (RJ.S.), and NHMRC project grant 1057741 (RJ.S.). S.K.G. and R.X are supported by La Trobe University Postgraduate Scholarships.